Ozone Therapy

Ozone Therapy

Ozone therapy is scientifically valid with hundreds, if not thousands of published research papers supporting its mechanisms of action, biological effects, effectiveness and safety.

It is used by certified doctors worldwide due to its numerous therapeutic properties. Ozone therapy has been widely used in medicine for over 80 years. The first ozone generator was patented in 1896 by Nikola Tesla. During WWI, topical ozone therapy was used by doctors on the battlefields to disinfect and heal wounds. In 2010, the Alvarado and Miramar water treatment plants of San Diego, California, initiated the use of ozone as their primary disinfectant. Today, trained and certified ozone therapy doctors all over the world utilize this therapy to treat a wide range of conditions. Multiple different international organizations of ozone therapy exist (Please visit “Ozone Organizations” page for more information”). In the United States, there are only small number of doctors trained and certified in ozone therapy.


Ozone gas consists of three oxygen atoms as opposed to the two oxygen molecules found in the air we breathe. It occurs naturally and creates the ozone layer, Earth’s protective layer from the Sun’s ultraviolet radiation.

Ozone therapy is a novel, safe, and effective therapy that utilizes medical grade oxygen/ozone gas created by an advanced medical device in a certified doctor’s office. Ozone therapy is typically used for its tissue regenerative, immune-supportive, anti-oxidant, anti-inflammatory, anti-septic, and anti-aging properties. The effects of Ozone therapy are proven, safe, and with minimal or no side effects.

  • Reduce chronic inflammation (oxidative stress)
  • Support tissue repair (enhances the release of growth factors)
  • Increase cellular energy
  • Reduce oxidized LDL (“bad cholesterol”)
  • Improve oxygen delivery to cells and circulation
  • Up-regulate the antioxidant system
  • Modulate the immune system

Ozone therapy has many clinical applications and a number of ways to administer it, depending on the health condition to be addressed. It is administered in a number of different ways; the most common is intravenous (IV) ozone which involves removing a volume of the patient’s blood (Typically 50-250 ml) into a sterile container containing an anticoagulant to prevent the blood from clotting. This volume of blood is then treated with ozone and then infused into the patient via an IV drip. Other methods administration include musculoskeletal injections (called P-zone which is similar to Prolotherapy and Platelet Rich Plasma), topical applications, and rectal and bladder insufflation. Direct injection of ozone gas into the venous or arterial system is no longer a commonly used technique due to many reported adverse effects.


P-zone therapy is the combination of prolotherapy and ozone therapy. A small volume of Ozone gas is injected into tendons, ligaments, joint capsules and joint spaces following prolotherapy injections. Ozone therapy further supports tissue repair by improving oxygen delivery to damaged or injured tissues, improving circulation, stimulating a cascade of growth factors including platelet derived growth factor (PDGF), transforming growth factor-b1 (TGF-b1), and vascular endothelial growth factor (VEGF). Furthermore, P-zone is especially effective for reduction pain. P-zone therapy can be used to address a variety of conditions including, arthritis, osteoarthritis, chronic joint pain, joint instability, spine pain, frozen shoulder and rotator cuff injuries, golfer’s elbow, tennis elbow, degenerative disc disease and others.


Ozone therapy has a wide range of therapeutic uses along with an array of mechanisms of actions. It is thought to exert most of its therapeutic effects by activating various nuclear transcription factors. Nrf2 (nuclear factor erythroid 2 related factor) and ARE (antioxidant response element) reduce NFkB and stimulate the production of numerous antioxidant enzymes including Catalase, SOD, GPx, HO-1, HSP10 and others. NFAT (nuclear factor of activated T cells) and AP-1(activated protein-1) modulate the immune system and reduce cytokine mediated inflammation. HIF-1 (hypoxia inducible factor-1) increases VEGF, EPO and glycolytic enzymes and is implicated in Ozone’s versatility in treating cardiovascular and neurodegenerative diseases.

* For more information on how Ozone Therapy works please visit the “Ozone Therapy Research and Literature Archive” page.


Ozone therapy has a wide range of therapeutic uses. Ozone therapy is typically used for its tissue regenerative, anti-oxidant, immune-supportive, anti-inflammatory, anti-septic and anti-ageing properties. Published research articles have demonstrated positive results in:

  • Chronic inflammation
  • Fibromyalgia
  • Chronic fatigue syndrome
  • Peripheral Artery Disease
  • Cerebral Vascular Disease
  • Intermittent Claudication
  • Diabetes and associated complications including ulcers
  • Post Stroke (Acute cerebral infarction)
  • Chronic viral hepatitis
  • Herpes/Shingles outbreak
  • Back pain
  • Disc herniation (Lumbar and Cervical)
  • Multiple sclerosis
  • Eye Conditions (age-related macular degeneration, diabetic retinopathy, glaucoma)
  • Dental and gum infections
  • Canker sores
  • And more…

*For more information on conditions treated with Ozone Therapy please visit the “Ozone Therapy Research and Literature Archive” page.

Ozone therapy has also been reportedly used in the treatment of:

  • Acute cold/flu
  • Environmental and seasonal allergies
  • Rheumatoid Arthritis
  • Ebola
  • SARS
  • Cancer
  • And more…

When administered by a certified and trained doctor, ozone therapy is extremely safe. The most common non-serious adverse effects include mild, swelling, bleeding, and bruising at the injection site. The inhalation of ozone gas can lead to airway hyper-reactivity and inflammation which can significantly exacerbate patients with chronic obstructive pulmonary disease (COPD). Similar to other injection therapies, there is a potential risk of infection, light headedness and blood clot. However, using universal safety precautions these risks are significantly reduced, if not completely eliminated. In 1980 the German Medical Society for Ozone Therapy surveyed 644 ozone therapists and found that of 5.5 million ozone treatments of 384,775 patients, the complication rate was 0.000007% (1 in every 137, 500 treatments). During your consultation, the doctor will discuss ozone therapy with you and decide if it is safe and indicated for you. Our doctors use universal safety precautions and a well-ventilated exam room to ensure the safety of all patients.


The number and frequency of treatment varies with the severity of your condition, age and overall health status. The number of total treatments can be up to 20 and the frequency can be as often as three times weekly. One of our experienced doctors will perform a thorough evaluation and decide the most appropriate number and frequency of treatments.